- Q: Can I use "Let me handle this!" or "You handle this one!" on a weakness? A: No. Both of these cards are played after you or another investigator draw a non-peril encounter card, but before resolving that card’s effects. Weaknesses with an encounter cardtype (such as enemies or treacheries) are considered to be encounter cards while they are being resolved and once they have entered play, but are not considered to be encounter cards yet at the time that these cards are played. Therefore, at the time these cards would be played, they are still player cards and are not legal targets. - FAQ, v.1.3, May 2018
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It's no coincidence Finn Edwards shows up in the artwork of this card, as he exemplifies the type of rogue that wants (and needs) this card.
Rogue have notoriously bad , presenting only a single 4 investigator and a single 3 investigator. They also have the only two 1 invesigators in the game, beaten out only by Calvin Wright, who still outshines them with a built in booster.
Rogues are then desperate for ways to withstand the horrors of the encounter deck, and the selection of in-class cards at their disposal to achieve this is... pitiful. Dario El-Amin, Moxie and Tennessee Sour Mash (and it's upgrade) represent the only boosting cards in their arsenal (as of Dream-Eaters), and the first two examples are far too unreliable (the third is an auto-include for some investigators). The only other cards that technically aids in dealing with the encounter deck is Cheat Death, a 5xp sink that won't see much time in any deck as a result.
It's so bad for rogues that THEY DON'T EVEN HAVE A CARD WITH TWO ICONS ON IT, with the not that relevant, technical exceptions of The Gold Pocket Watch and All In. Really, in order to inure a rogue against getting screwed over by the encounter deck, you need to rely on neutral or out-of-class cards that, fortunately, is an option for every rogue character. Still, those are precious card slots getting occupied before any other card can be considered, especially when you're only allowed up to 5 out-of class cards, as Jenny Barnes and Finn Edwards are restricted to.
Thus, I say with confidence that "You handle this one!" is a must-have for all the rogues with 2 or less, and a serious consideration for any 2 or less investigator that can take it. Of course it's efficacy will vary depending on the scenario and campaign, but remains the most tested attribute from revelation effects, and horror remains the most common punishment from treachery cards. And it goes without saying that you don't play this in a one-handed solo campaign, for obvious reasons.
Now, I've ignored its glaring downside until now, namely that someone's footing the bill for your brief respite from the encounter deck, and you may not feel comfortable saddling some poor sod around the table with your problems, especially if the're your friend.
Thing is, in many a case, your fellow investigators will be grateful for you sending treacheries their way, guardians and mystics who've run encounter-hate cards specifically. A guardian will generally be appreciative of the time-saver of having an enemy spawn on them, rather than have to use actions to move/engage an enemy someone else drew. Likewise, a mystic running Ward of Protection will be hoping to be the one to draw Ancient Evils to prevent an entire round's worth of turns being skipped. Having "You handle this one!" can enable their encounter-hate more effectively.
But even without that archetype, having a 4+ investigator in your team is enough to justify taking "You handle this one!", doubly so if said investigator has a high sanity threshold (which is correlated with high ). It is a co-operative game, after all; your well-being directly benefits the group, and no-one wants to see one player struggle turn after turn to discard a Frozen in Fear.
A final word; until more rouge encounter-insurance cards get released, investigators like "Skids" O'Toole and Finn Edwards are going to have to justify not taking "You handle this one!" every campaign. Doesn't matter if it and Tennessee Sour Mash are or aren't good; the fact of the matter is, the're just aren't any other options (or so I claim, I would really like to be proven wrong on this one).