EDIT: Ignore all of the following, apart from maybe the bit about Dunwich Legacy... after not playing for several months, I completely forgot how SttP worked. It can't work w/ Predator Or Prey, so everything I wrote is irrelevant.
+++
A lovely Guardian card! Guardians have relied on their teammates to push them around for months; finally they can give a nudge back.
The obvious combo is with that staple of all sensible Guardian decks: Stick To The Plan. Since drawing this card at random from your deck literally turns it into a signature weakness, you just need to put it where you can see it 100% of the time.
So, Zoey/Tommy/Marky likey! Other Guardians too, tho they sort of need 1 more combo piece.
Once it's Stuck, your Guardian now has a 0-cost party-wide Elusive-lite, a map-wide Get Over Here-lite, or in some rare circumstances, (DUNWICH LEGACY SPOILERS) a straight-up scenario breaker. (Serves him right. He knows what he did.).
Lastly- and this is just sort of an esoteric novelty for the sake of being thorough- Survivors can take it too.