
Nathaniel Cho is fun and unique to play with a fighting style unlike any other investigator. However, at my tables Nathaniel Cho has also earned a reputation as one of the most fragile guardians, being very vulnerable to the many treacheries that discard your hand and resources.
Other guardians are still capable of effective combat even after losing their entire hand and all their resources if they've their weapons out. But Nathaniel Cho's reliance on fight events means that if those events are randomly discarded by a treachery, or if he no longer has the resources to play that "Get over here!" or One-Two Punch, he might become unable to effectively fight at all. And if your teammates happened to draw enemies on the same turn, you'll end up in a bad board state.
It's not that this can't happen to other guardians — running out of ammo with a Extra Ammunition in hand, for example — but it's far more likely to happen for poor Cho. Make sure your team is able to make up for it by packing evasion or supplementary fighting tools, or when they have to make the choice on Syzygy. The new Brand of Cthugha serves as an excellent slotless backup weapon.